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PAMSys™

Continuous monitoring of body postures, postural transitions, and walking from a single wearable sensor.

PAMSys is an FDA-listed, pendant-worn sensor that measures body posture, postural transitions, and walking patterns during daily life. It offers up to 3 months of battery life with walking-only recording, onboard storage, and wireless charging between recording periods.

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PAMSys accepted into the FDA ISTAND program

The FDA ISTAND program has accepted a Letter of Intent for PAMSys-derived ambulation measures as longitudinal outcomes in clinical trials of progressive supranuclear palsy–Richardson syndrome (PSP-RS).

View the qualification pathway

A broader view of daily physical activity

Daily function involves how much people walk, how they move between postures, and how activity varies throughout the day. PAMSys measures these patterns with a single wearable sensor, bringing walking, posture, and transition measures together with wear-time information. Additional research measures include activity intensity, estimated sleep, and detected falls.

PAMSys has been used in more than 100 clinical studies across over 30 countries. Its measures have served as primary or secondary endpoints in more than 10 clinical trials.

What PAMSys measures

PAMSys reports 27 daily physical activity parameters, including walking, posture, and postural-transition measures. Depending on the parameter, outputs include totals, durations, averages, medians, and percentile summaries.

  • Walking and running

    Walking and running bouts, step counts, cadence, bout duration, and step-duration variability.

  • Posture and activity states

    Time spent sitting, standing, walking, running, and lying down, with percentage summaries.

  • Postural transitions

    Sit-to-stand and stand-to-sit transition counts throughout the day.

  • Wear adherence

    Estimated wear time and non-wear periods help study teams assess adherence and interpret activity data.

Additional parameters (research only)

Additional research measures provide context about activity intensity, estimated sleep, and falls alongside the standard activity parameters.

  • Activity level

    Estimated time in sedentary, moderate, and vigorous activity, with the start and end times of each period.

  • Sleep-related estimates

    Lying periods and sensor-derived estimates of sleep onset latency, wake after sleep onset, and total sleep time.

  • Falls and related activity

    Detected fall events and their timing, alongside activity measures for fall-risk research.

  • Raw data access

    Access to raw sensor data for study-specific analyses.

Designed for real-world monitoring

Designed for extended activity recording outside the clinic, with onboard storage, wireless charging, and automated analysis.

  • Single lightweight sensor

    One lightweight pendant records daily movement, posture, and walking patterns with a simple wear routine.

  • Up to 3 months of battery life

    Battery life of up to 3 months with the walking-only recording configuration, which records raw accelerometer data only during walking; onboard storage and wireless charging support extended monitoring.

  • FDA-listed, CE marked

    Listed with the FDA as a Class II device and CE marked under the EU Medical Device Regulation (2017/745). Device selection follows the study's intended use and regional requirements.

  • Wear-time information

    Algorithms identify likely non-wear periods, helping researchers distinguish time without usable wear data from low activity.

  • Measurements from daily life

    Captures activity at home and in the community, adding daily-life context to structured clinic assessments.

  • Pairs with PAMSys ULM

    Combine the PAMSys pendant with PAMSys ULM wrist sensors to measure daily mobility and upper-limb movement within one study protocol.

Advancing ambulation measures for PSP trials

The FDA's Innovative Science and Technology Approaches for New Drugs (ISTAND) program supports the development and qualification of novel drug development tools. PAMSys has been accepted into the program for measuring ambulation in PSP clinical trials. Qualification would establish a defined context of use for the measures.

  • Accepted into the FDA ISTAND program

    PAMSys measures ambulation during everyday life to support assessment of change over time in PSP clinical trials. Program acceptance is distinct from FDA qualification for a defined context of use.

  • Ambulation measured in daily life

    The proposed measures are derived from continuous at-home recording with the PAMSys pendant. They describe walking during daily routines and are being developed to complement established clinical assessments.

PAMSys specifications

PAMSys specifications
Specification Details
Form factor Single lightweight pendant-worn sensor
Sensors 3-axis accelerometer
Activity monitoring Signal-processing algorithms for body posture, postural transitions, and walking parameters
Parameters 27 daily physical activity parameters
Battery and memory Up to 3 months of battery life with the walking-only recording configuration, with onboard storage; wireless charging
Wear adherence Estimated wear time and algorithmic identification of non-wear periods
Data output Processed activity parameters, per-step timestamps and durations, plus raw sensor data
Monitoring mode Continuous recording during wear
Cloud integration BioDigit Cloud: centralized study data portal with API access
Regulatory and quality FDA-listed Class II device; CE marked under EU MDR 2017/745; ISO 13485 quality management. Study data protection controls support HIPAA and GDPR obligations

PAMSys research across disease areas

Explore daily activity and mobility research across the populations below. Selected clinical, sensor, and digital assessment datasets are available through BioDigit Database, subject to study-specific access terms. Contact BioSensics about current cohort coverage and available measures.

  • Healthy controls

    Reference data from participants without the target condition support comparisons with patient cohorts and analysis of variation in daily activity.

  • Amyotrophic lateral sclerosis

    Daily walking and posture measures support research on mobility and physical activity in amyotrophic lateral sclerosis.

  • Alzheimer's disease

    Daily activity, walking, and sleep-related estimates provide context for research on functional change over time.

  • Charcot-Marie-Tooth disease

    Wearable activity measures can be examined alongside clinical scores to study mobility in Charcot-Marie-Tooth disease.

  • Corticobasal syndrome

    Daily activity and posture measures support investigation of mobility patterns in corticobasal syndrome.

  • Friedreich's ataxia

    Activity measures support investigation of daily mobility and its relationship with established clinical assessments.

  • Huntington disease

    Research in prodromal and manifest Huntington disease examines relationships between daily activity, disease stage, and clinical scores.

  • Inclusion body myositis

    Daily activity and walking measures complement clinical assessments in inclusion body myositis research.

  • Myasthenia gravis

    Activity patterns provide context for studying fluctuating function alongside fatigue, weakness, and clinical assessments.

  • Progressive supranuclear palsy

    Longitudinal walking, posture, and activity data support research on mobility changes in progressive supranuclear palsy.

  • Spinocerebellar ataxia

    Daily physical activity and walking measures support research on mobility in spinocerebellar ataxia.

PAMSys publications and presentations

Selected journal articles and conference abstracts explore the use of PAMSys for daily activity measurement, clinical research, and digital biomarker development.

Part of the BioSensics ecosystem

Combine PAMSys with other BioSensics devices and assessments within one study protocol, with supported study data accessible through BioDigit Cloud.

  • Gait monitoring

    PAMSys Gait

    Continuous real-world gait monitoring with stride-level metrics from a single ankle-worn sensor.

  • Upper-limb monitoring

    PAMSys ULM

    Wrist-worn monitoring of upper-limb movement during daily activities.

  • At-home monitoring

    BioDigit Home

    Remote collection of speech, video, cognitive, and patient-reported assessments from participants at home on a single study device.

  • Fall monitoring

    PAMSys Fall

    Pendant-worn monitoring that identifies potential falls to support fall-frequency measurement in clinical research.

Bring PAMSys into your study

Talk to our team about the activity measures, monitoring schedule, and data outputs that fit your clinical trial or research study.

Request a demo