Amyotrophic lateral sclerosis

Developing digital health technologies to monitor disease symptoms in ALS, including physical activity level, fatigue, falls, upper limb function, fine motor control, and speech difficulties (dysarthria).

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that affects nerve cells in the brain and spinal cord. ALS primarily affects motor neurons, the nerve cells responsible for controlling voluntary muscles. Symptoms typically begin subtly and progressively worsen over time. The exact cause of ALS is not well understood, and there is no cure for it.

Our research in ALS is focused on developing a multi-modal digital health technology for monitoring disease symptoms. This includes the use of 1) wearable sensors for tracking lower and upper limb dysfunction, as well as fall frequency over time, 2) BioDigit Speech to assess speech difficulties and dysarthria, and 3) Digital fine motor control assessments including pattern tracing and hand writing to measure fine motor control decline over time.

Our clinical study in ALS

BioDigit ALS ID: NCT05271435

Status: Recruiting
Number of participants: 30
Monitoring period: 12 months
Study product: BioDigit ALS, PAMSys, PAMSys Fall, PAMSys ULM

BioDigit ALS2 ID: NCT06315673

Status: Recruiting
Number of participants: 30
Monitoring period: 1 clinical visit
Study product: BioDigit ALS

BioDigit ALS solution

BioDigit ALS is a multi-modal digital health technology designed for objective, precise and frequent monitoring of symptoms in ALS. Developed in collaboration with ALS experts and incorporating patient feedback, this technology aims to enhance disease evaluation and management.

The solution incorporates several BioSensics products to provide comprehensive monitoring of ALS symptoms through a single digital health solution:

  1. PAMSys and PAMSys Fall wearable sensors for precision actigraphy and measuring fall frequencies.

  2. PAMSys ULM for continuous monitoring of upper limb function.

  3. BioDigit Speech for frequent assessment of speech dysfunction and dysarthria

  4. Digital fine motor control assessments, including multiple pattern writing and handwriting assessments, for frequent at-home measurements

Our research partners

If you're interested in discussing our research, including access to our study protocol and data, or using our products in your clinical trials and research, please contact us.

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