Therapeutic area

Corticobasal syndrome

Developing and evaluating wearable sensors and digital assessments to track motor, speech, and cognitive function in corticobasal syndrome.

Corticobasal syndrome (CBS) is a rare, progressive neurological syndrome that affects movement and may also affect thinking, language, and behavior. Symptoms often begin on one side of the body and can include stiffness, abnormal postures, and difficulty performing purposeful movements. CBS can arise from several underlying brain diseases, including corticobasal degeneration; the two terms are not interchangeable.

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$2.5 million DoD award supports CBS and FTD research

In 2024, BioSensics received an approximately $2.5 million, four-year contract through the Department of Defense Congressionally Directed Medical Research Programs (CDMRP) to develop and evaluate digital measures for CBS and FTD.

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Our research in CBS

Our CBS research is supported by DoD CDMRP and a separate award from the Association for Frontotemporal Degeneration and the ALS Association. We focus on two areas: developing digital measures of motor, speech, and cognitive function, including upper and lower limb activity, and building longitudinal datasets to support clinical research.

  • Multimodal monitoring

    Digital measures to study changes in CBS

    Wearable sensors and digital tasks to study motor, speech, and cognitive function, with a focus on changes in upper and lower limb activity.

  • Longitudinal datasets

    Longitudinal data for clinical research

    Repeated measurements of daily activity and task performance to help characterize changes in function between clinical visits.

Digital measures to study changes in CBS

We combine wearable sensors with digital assessments to study movement, speech, cognition, and daily function. Developed with clinical experts and informed by patient experience, this approach is being evaluated for its ability to measure changes over time. A central question is whether wearable measures reflect changes in upper and lower limb function in CBS.

  • PAMSys and PAMSys Fall

    Wearable measures of daily activity and movement, with PAMSys Fall identifying potential falls for study review.

  • PAMSys ULM

    Wrist-worn sensors that quantify upper limb activity and identify movement patterns consistent with goal-directed use.

  • LEGSys

    Wearable gait analysis during structured walking assessments at home to track changes over time.

  • BioDigit Speech

    Standardized speech tasks and automated analysis to study changes in speech production and motor speech function.

  • Cognitive and fine motor assessments

    Digital tasks designed for repeated assessment of cognitive performance and fine motor control at home.

  • Oculomotor assessments

    Video-based tasks using BioDigit Video to record eye movements for research assessment.

Our clinical study in CBS

BioDigit FTLD-03 is an observational study designed to evaluate digital measures across frontotemporal lobar degeneration (FTLD) syndromes, including CBS. The study plans to follow 20 participants in total for 12 months, with visits every three months. The April 2026 registry record lists the study as not yet recruiting.

Our research partners

Our CBS research brings together academic medical centers and patient advocacy organizations.

  • ALS Association
  • Association for Frontotemporal Degeneration
  • Johns Hopkins University
  • Massachusetts General Hospital

Advance CBS research with digital measures

Bring everyday function into CBS research. Contact our team to discuss research collaborations, study protocols, data access, or the use of digital measures in your clinical studies.

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