Therapeutic area

Inclusion body myositis

Evaluating wearable measures of daily mobility and upper-limb function in inclusion body myositis.

Inclusion body myositis (IBM) is a rare, progressive muscle disease characterized by inflammation, weakness, and muscle wasting. Weakness often affects the thighs and fingers, making walking, rising from a chair, and gripping objects more difficult. Swallowing can also be affected. The underlying causes are not fully understood.

Talk to our team Explore our research

A longitudinal study of daily function in IBM

BioDigit IBM combines repeated clinical assessments with periods of wearable recording at home. The reported 24-month protocol examines daily mobility and upper-limb movement alongside established clinical measures.

Explore our clinical study

Our research in IBM

Our IBM research focuses on two complementary areas: evaluating wearable-derived movement measures alongside clinical assessments, and building longitudinal datasets to study daily function over time.

  • Wearable monitoring

    Evaluating digital measures in IBM

    Studying how measures of daily activity and upper-limb movement relate to clinical assessments and change over time.

  • Longitudinal datasets

    Longitudinal datasets for IBM research

    Repeated wearable recordings and clinical assessments provide complementary perspectives on function and support digital biomarker research.

Evaluating digital measures in IBM

Our research combines wearable recordings from daily life with clinical assessments of strength and function. PAMSys and PAMSys ULM provide measures of activity, walking, and upper-limb movement during scheduled recording periods. Preliminary conference findings report associations with clinical rating scales, supporting further evaluation of these measures in IBM.

  • PAMSys

    A pendant-worn sensor records walking, posture, and postural transitions to characterize physical activity during daily life.

  • PAMSys ULM

    Wrist-worn sensors record movement from each monitored limb. Algorithms identify patterns consistent with goal-directed upper-limb use.

Our clinical study in IBM

The reported BioDigit IBM protocol follows participants for 24 months, with clinical assessments every six months and seven-day periods of at-home wearable recording. Researchers compare sensor-derived measures with strength assessments, the IBM Functional Rating Scale, and participant reports.

Our research partners

Our IBM research is conducted in collaboration with academic medical centers, patient advocacy organizations, and industry partners.

  • Abcuro
  • Myositis Support and Understanding
  • University of Kansas Medical Center

Selected publications and presentations

Advance IBM research with digital measures

Explore collaboration in IBM research. Talk with our team about study design, research data access, and the use of digital measures in clinical trials.

Talk to our team